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Chip BDF Custom

Be-Doubleflow Custom

400,0

BE-Doubleflow: is our most advanced device. It consists of two perfusable channels connected via a porous membrane. Explore the crosstalk between different 2D and 3D cultures in a biomimetic environment and control the efficiency of the interaction by selecting the optimal pore size for your application. This is the optimal device when a hypoxia environment is needed, for studying the effect of circulating particles (bacteria, immune system, circulating tumor cells) and for endothelium/epithelium barrier when no ALI is needed or when flux plays a role in both sides of the coculture.

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· 10 devices per box

· Contact us for special requests

· For more information please Download the Technical PDF

Chip BDF Custom

Be-Doubleflow Custom

400,0

BE-Doubleflow: is our most advanced device. It consists of two perfusable channels connected via a porous membrane. Explore the crosstalk between different 2D and 3D cultures in a biomimetic environment and control the efficiency of the interaction by selecting the optimal pore size for your application. This is the optimal device when a hypoxia environment is needed, for studying the effect of circulating particles (bacteria, immune system, circulating tumor cells) and for endothelium/epithelium barrier when no ALI is needed or when flux plays a role in both sides of the coculture.

Product total
Options total
Grand total

· 10 devices per box

· Contact us for special requests

· For more information please Download the Technical PDF

Worldwide commercial network

We ship our products worldwide working with the best carriers.

Delivery time

Fast and efficient delivery times.

After-sales support

Live communication for assist you throughout all the process.

Worldwide commercial network

We ship our products worldwide working with the best carriers.

Delivery time

Fast and efficient delivery times.

After-sales support

Live communication for assist you throughout all the process.

Worldwide commercial network

We ship our products worldwide working with the best carriers.

Delivery time

Fast and efficient delivery times.

After-sales support

Live communication for assist you throughout all the process.

Be-Doubleflow Custom

Explore the crosstalk in the endothelium epithelium barrier under flow in both channels of the device, mimicking a more physiological environment for the study of different organs such as kidney, liver, gut or heart, among others.

Combine 3D and 2D cultures in a hypoxia environment where oxygen is supplied to the cells via the medium flowing in one of the channels.

Research the effect of circulating particles such as circulating tumor cells, immune system cells, bacteria, fungi, viruses and many more in a single cell culture, or in a complex coculture.

This device comprises two fluidic channels separated by a porous membrane that facilitates interaction between one channel and another while serving as a platform for the culture of different cell types. Some applications with this device include:

  • Epithelial/endothelial barrier models where shear stress plays a relevant role: lung, gut, kidney, liver, eye.
  • Gas control for anaerobic and hypoxic environments in the chip, adapting to changes in cell culture conditions and precise nutrient supply through perfused media. For example, creating an optimal environment for intestinal microbiota growth.
  • Muscle models: Co-culture of muscle layer with vasculature subjected to relevant shear stress.
  • Co-cultivation in both 2D and 3D
  • Unfolding organoids onto the porous membrane.
  • Invasion, cell migration, and metastasis processes between compartments by selecting the appropriate pore size.
  • Circulating particle assays involving immune system cells, vesicles, nanoparticles, encapsulated drugs, circulating tumor cells, bacteria, virus, under blood flow conditions.
  • Rolling and adhesion assays to study the ability of cells like leukocytes to adhere and roll on an endothelial surface, allowing for the final process of diapedesis and transmigration.

 Compatible techniques for device use:

  • High-resolution microscopy for live and fixed cells: immunofluorescence.
  • Cell extraction for flow cytometry, qPCR, or western blot.
  • Liquid exchange control and automation.
  • Permeability assays.
  • Optical mapping.
  • Plate reader.

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If you want to know more information about our products or want to request any of these, please contact us.

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